Pekka Lappalainen's Actin-Monomer-Binding Proteins PDF

By Pekka Lappalainen

ISBN-10: 0387464050

ISBN-13: 9780387464053

ISBN-10: 0387464077

ISBN-13: 9780387464077

The actin cytoskeleton performs a crucial position in lots of mobile approaches together with phone motility, cytokinesis, endocytosis and phagocytosis. The constitution and dynamics of the actin cytoskeleton is regulated through lots of proteins that engage with monomeric and/or filamentous actin. Actin monomer binding proteins offers a accomplished view on actin monomer-binding proteins and the mechanisms wherein they give a contribution to actin dynamics and numerous actin-dependent mobile approaches. This new name comprises chapters that describe the elemental mechanisms of actin dynamics in addition to the structural rules wherein numerous actin-binding proteins engage with actin.

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Action of a 19K protein from porcine brain on actin polymerization: A new functional class of actin-binding proteins. J Biochem (Tokyo) 1984; 95(2):387-398. ADF/Cofilin Proteins 23 7. Nishida E, Muneyuki E, Maekawa S et al. An actin-depolymerizing protein (destrin) from porcine kidney. Its action on F-actin containing or lacking tropomyosin. Biochemistry 1985; 24(23):6624-6630. 8. Cooper JA, Blum J D , Williams Jr R C et al. Purification and characterization of actophorin, a new 1 5 , 0 0 0 - d a l t o n a c t i n - b i n d i n g protein from A c a n t h a m o e b a castellanii.

The pathway leading to cofilin translocation has yet to be resolved, however it seems that cofilin performs dual roles during apoptosis: an early role supporting cytochrome c release, and a later role in the cytosol establishing and maintaining apoptotic blebs. Conclusions and Future Perspectives Actin plays a central role in most dynamic cellular processes and thus it is not surprising to find important roles for AC proteins in a myriad of biological systems. However, AC proteins do not fijnction alone in regulating actin dynamics, and it is the complex interplay of AC with actin and with the AC regulatory machinery that controls spatial and temporal changes in actin filament turnover.

Comparison of plant and human ADFs and effect of phosphorylation. J Biol Chem 1998; 273(33):20894-20902. 54. Moriyama K, lida K, Yahara I. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1996; l(l):73-86. 55. Nebl G, Meuer SC, Samstag Y. Dephosphorylation of serine 3 regulates nuclear translocation of cofilin. J Biol Chem 1996; 271(42):26276-26280. 56. Kanamori T, Suzuki M, Titani K. Complete amino acid sequences and phosphorylation sites, determined by Edman degradation and mass spectrometry, of rat parotid destrin- and cofilin-like proteins.

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Actin-Monomer-Binding Proteins by Pekka Lappalainen

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