Ed Harlow and David Lane's Antibodies - A LABORATORY MANUAL PDF

By Ed Harlow and David Lane

ISBN-10: 0879693142

ISBN-13: 9780879693145

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Michael, A. M. Prager, M. E. J. E. C. Wilson. 1984. The antigenic structure of proteins: A reappraisal. Annu. Rev. lmmunol. 2:67-101. Landsteiner, K. 1936. The specificity of serological reactions. C. Thomas, Springfield, Illinois. , J. Deisenhofer, R. Huber, and W. Palm. 1980. Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3 ·A and 1 ·A resolution. J. Mol. Biol. 141: 369-391. H. A. R. Davies. 1986. 7A. J . Mol. Biol. 190: 593-604.

Although these studies have shown that epitopes can be much larger than originally thought, it is still clear that high-affinity antibodies can be raised to small epitopes. Because antibodies can recognize relatively small regions of antigens, occasionally they can find similar epitopes on other molecules. This forms the molecular basis for cross-reaction. Although similar epitopes can occur on related molecules, the presence of similar epitopes does not necessarily imply a functional relationship.

J. Poljak. 1986. 8 A resolution. Science 233:747- 753. G. N. T. A. M. G. Webster. 1987. Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature 326:358- 363. W. A. H. J. C. R. Davies. 1987. Three-dimensional structure of an antibodyantigen complex. Proc. Natl. Acad. Sci. 84:8075- 8079. M. G. N. T. R. A. G. Laver. 1987. How antibodies recognize virus proteins. lmmunol. Today 8:323- 326. R. 1987. The ant ibody combining site: Retrospect and prospect. lmmunol.

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Antibodies - A LABORATORY MANUAL by Ed Harlow and David Lane

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