By Richard J. Davidson
By way of targeting the connection among simple examine in emotion and emotional disorder in melancholy and nervousness, this detailed quantity offers either mental and organic implications of analysis for psychiatrists and psychologists.
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19 41 42 In summary, results obtained from microinjecting GAL into VTA to determine if this will produce depression-like symptoms reveal that VTA-GAL reduces various kinds of motor activity, including spontaneous ambulatory activity in a novel environment, struggling behavior in the swim test by animals that have been bred for high levels of struggling activity, and floating behavior (â immobilityâ ) in the swim test by normal, nonselected animals. The data gathered to date indicate that (a) such effects can be obtained by injecting very low concentrations of GAL, (b) the effects are specific to introduction of GAL into the VTA region of the brain, and, (c) the effects of GAL in VTA can be blocked by introduction of an antagonist to GAL receptors.
Consequently, we have sought to develop better animal models than are presently available. For approximately 10 years, we have been using selective breeding techniques in an attempt to develop new rat models for depression and/or to substantially improve rodent models already in use. The rationale underlying this approach is that serious mental illness is characterized by genetic susceptibility and, consequently, better animal models are likely to be based on specific strains of animals that either spontaneously display relevant behavioral characteristics or readily express such behavior under appropriate environmental conditions, such as when exposed to stressful circumstances.
Are the Models Generated by Selective Breeding Relevant to Clinical Pathology? An important concern regarding any line of selectively bred animals that is generated for the purpose of studying a clinical pathology is whether the resultant animal subject really possesses aspects of the underlying pathophysiology of the disorder, or whether the characteristics elaborated and/or reinforced by selective breeding are due to some cause (albeit genetically determined) that is unrelated to the clinical pathology one wishes to explore.
Anxiety, Depression, and Emotion by Richard J. Davidson